Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (1085)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Activators (234)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-12550

GW542573X	Activator	99.79%
GW542573X is a potent and selective Ca²⁺-activated K⁺ 2 (SK2) channels activator. GW542573X induces the Ca²⁺-response curve of hSK1 that left-shifted from an EC₅₀ (Ca²⁺) value of 410 nM to 240 nM.

HY-14256

BMS-191095	Activator	98.01%
BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K(ATP) channels.

HY-101069

Y-26763	Activator	99.7%
Y-26763 is a K⁺ channel opener and active metabolite of Y-27152. Y-26763 is an ATP-sensitive K⁺ (K_ATP) channel activator.

HY-127106

VU0810464	Activator	99.29%
VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC₅₀=165 nM) and GIRK1/4 (EC₅₀=720 nM) channels with improved brain penetration.

HY-N3463

Isopimaric acid	Activator	99.88%
Isopimaric acid is a potent opener of large conductance calcium activated K⁺ (BK) channels.

HY-131012

GoSlo-SR-5-69	Activator	99.26%
GoSlo-SR-5-69 is a potent activator of large conductance Ca²⁺-activated K⁺ (BK) channels, with an EC₅₀ of 251 nM.

HY-175668

IDOR-1104-0086	Activator	98.98%
IDOR-1104-0086 is an orally active K_v7 potassium channel opener with an EC₅₀ of 210 nM that can cross blood-brain barrier. IDOR-1104-0086 displays strong selectivity against the hERG channel with an IC₂₀ of 25 μM. IDOR-1104-0086 exhibits efficacy in two rodent models of epilepsy and a favorable tolerability profile. IDOR-1104-0086 can used for the study of epilepsy.

HY-P0249A

Phe-Met-Arg-Phe amide trifluoroacetate	Activator	98.85%
Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K⁺ current, with ED₅₀ of 23 nM in the peptidergic caudodorsal neurons.

HY-178281

E0199	Activator	99.89%
E0199 is a novel potent dual-target K_V7/Na_V modulator that activates the K_V7 channel (K_V7.2/7.3 (EC₅₀ = 12.78 nM), K_V7.2 (EC₅₀ = 0.50 μM), and K_V7.5 (EC₅₀ = 27.14 nM) channels) while simultaneously blocks the Na_V1.7 (IC₅₀ = 0.52 μM), Na_V1.8 (IC₅₀ = 0.24 μM), and Na_V1.9 (IC₅₀ = 0.16 μM) channels. E0199 shows a potent analgesic effect without affecting heart and skeletal muscle ion channels critically in a chronic constriction injury (CCI) mouse model. E0199 can be used for Neuropathic pain (NP) research.

HY-B0122R

Topiramate (Standard)	Activator
Topiramate (Standard) is the analytical standard of Topiramate. This product is intended for research and analytical applications. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.

HY-113066S

Guanosine 5'-diphosphate-¹⁵N₅ dilithium	Activator	98.20%
Guanosine 5'-diphosphate-¹⁵N₅ (GDP-¹⁵N₅) dilithium is ¹⁵N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-12355A

Siponimod hemifumarate	Activator	99.64%
Siponimod (BAF-312) hemifumarate is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC₅₀ values of 0.39 nM and 0.98 nM, respectively. Siponimod hemifumarate induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod hemifumarate can be used in research related to multiple sclerosis.

HY-100418

SKA-111	Activator	99.97%
SKA-111 is a selective activator of potassium phannel K_Ca3.1 , evokes K_Ca3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research.

HY-B1221S1

Flufenamic acid-¹³C₆	Activator
Flufenamic acid-¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-113066S1

Guanosine 5'-diphosphate-¹³C₁₀ dilithium	Activator	98.7%
Guanosine 5'-diphosphate-¹³C₁₀ (GDP-¹³C₁₀) dilithium is ¹³C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-W011641R

(±)-Naringenin (Standard)	Activator
(±)-Naringenin (Standard) is the analytical standard of (±)-Naringenin. This product is intended for research and analytical applications. (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BK_Ca channels in myocytes.

HY-N4237

Saikogenin D	Activator	99.99%
Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca²⁺]i due to Ca²⁺ release from intracellular stores.

HY-101981S2

Uridine 5'-monophosphate-d₁₁ dilithium	Activator	99.90%
Uridine 5'-monophosphate-d₁₁ (5'- Uridylic acid-d₁₁) dilithium is deuterium labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

HY-122024

AZSMO-23	Activator	99.87%
AZSMO-23 is a potent hERG K⁺ channel activator. AZSMO-23 activats WT hERG pre-pulse and tail current with EC₅₀ values of 28.6, 11.2 µM, respectively. AZSMO-23 has the potential for the research of long QT syndrome.

HY-113673

A-935142	Activator	98.77%
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization.

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

320compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (1085)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (1085):